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The results allowed for describing time courses of five known compounds, namely catechin, taxifolin, caffeic acid, ferulic acid and the gut microbial metabolite 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone (see also section “6.1 Pre-systemic metabolism: role of gut microbiota”)

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Thus, sertraline induces testicular toxicity in a dose-dependent manner, and enhanced OS and changes in hormone levels may be the key mechanisms